Biotransformation of (-)-α-Santonin by Aspergillus parasiticus and Antimicrobial Efficacy of the Transformed Products

Author(s): Busi Siddhardha , Ramakrishna Gadupudi , Mandava Venkata Basaveswara Rao .

Journal Name: Current Biotechnology

Volume 1 , Issue 3 , 2012

Become EABM
Become Reviewer


Biotransformation of (-)-α-santonin using Aspergillus parasiticus resulted in the production of 3,4-epoxy-α-santonin, 4,5-dihydro-α-santonin and 1,2-dihydro-α-santonin and 3 minor products and the biological activity of the transformed products was established by antibacterial & antifungal assays. 3,4-epoxy-α-santonin exhibited higher degree of antibacterial and antifungal activity. 4,5-dihydro-α-santonin showed slight increase in the activity, compared to (-)-α-Santonin. 1,2-dihydro-α-santonin is equipotent to the substrate ( (-)-α-Santonin ). This is the first report on the Biotransformation of (-)-α-Santonin by Aspergillus parasiticus and evaluation of the biological activities of the biotransformed products.

Keywords: (-)-α-santonin, biotransformation, Aspergillus parasiticus, 3, 4-epoxy-α-santonin, 4, 5-dihydro-α-santonin, 1, 2-dihydro-α-santonin, antibacterial, Cytotoxic activity, regioselectivity, stereoselectivity, anti-HIV, Spectrometry, NMR Spectrum, Antibacterial Activity, Antifungal Activity

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2012
Page: [194 - 198]
Pages: 5
DOI: 10.2174/2211550111201030194
Price: $58

Article Metrics

PDF: 2