Biotransformation of (-)-α-Santonin by Aspergillus parasiticus and Antimicrobial Efficacy of the Transformed Products
Mandava Venkata Basaveswara Rao.
Biotransformation of (-)-α-santonin using Aspergillus parasiticus resulted in the production of 3,4-epoxy-α-santonin, 4,5-dihydro-α-santonin and 1,2-dihydro-α-santonin and 3 minor products and the biological activity of the
transformed products was established by antibacterial & antifungal assays. 3,4-epoxy-α-santonin exhibited higher degree
of antibacterial and antifungal activity. 4,5-dihydro-α-santonin showed slight increase in the activity, compared to (-)-α-Santonin. 1,2-dihydro-α-santonin is equipotent to the substrate ( (-)-α-Santonin ). This is the first report on the
Biotransformation of (-)-α-Santonin by Aspergillus parasiticus and evaluation of the biological activities of the
Keywords: (-)-α-santonin, biotransformation, Aspergillus parasiticus, 3, 4-epoxy-α-santonin, 4, 5-dihydro-α-santonin, 1, 2-dihydro-α-santonin, antibacterial, Cytotoxic activity, regioselectivity, stereoselectivity, anti-HIV, Spectrometry, NMR Spectrum, Antibacterial Activity, Antifungal Activity
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