Current Respiratory Medicine Reviews

Joseph Varon  
The University of Texas Health Science Center
Houston, TX


Descending Necrotizing Mediastinitis: Current Strategies for Diagnosis and Treatment

Author(s): Richard K. Freeman, Theresa Giannini, Amy Vyverberg, Anthony J. Ascioti.


Descending necrotizing mediastinitis is an acute, polymicrobial infection. Originating in the pharynx or neck, this necrotizing process descends into the chest producing widespread tissue necrosis. Despite the introduction of modern antimicrobial therapy and computed tomographic imaging, this form of mediastinitis has continued to produce reported mortality rates of 25% to 40%. This review discusses the pathophysiology, diagnosis and treatment of descending necrotizing mediastinitis with recommendations for treating physicians based on the modern literature.

Keywords: Descending, mediastinitis, necrotizing, polymicrobial infection, tissue necrosis, PATHOPHYSIOLOGY, cervicofascial infection, computed tomographic imaging, chest roentgenograms, modern.

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Article Details

Year: 2012
Page: [263 - 267]
Pages: 5
DOI: 10.2174/157339812802652224
Price: $58