Abstract
Platelet adhesion on vascular wall is the first step following vascular injury. Differential platelet secretion supports angiogenesis and vascular homeostasis. Progenitor cells are pluripotent cells responsible for tissue regeneration and wound healing. Upon ischemia bone marrow-derived progenitor cells are mobilized into peripheral circulation and domiciliate into peripheral organ vasculature and either give birth to a series of cardiovascular cells, including endothelial cells, macrophages, smooth muscle cells, or support in a paracrinic way the angiogenic capacity of local tissue cells. Mobilization, chemotaxis, adhesion, differentiation and interaction with vascular cells are essential steps of progenitor cellmediated tissue repair. This review summarizes the recent advances in our understanding of platelet function with focus on interaction with progenitor cells and its role in cardiovascular homeostasis. Moreover, the role of platelet microparticles in progenitor cell function is separately addressed. Understanding the mechanisms of platelet interaction with progenitor cells provides us with new insights in the mechanisms of vascular homeostasis and possible new therapeutical targets supporting vascular repair.
Keywords: Platelet, progenitor cells, angiogenesis, vascular homeostasis, ischemia, macrophages, chemotaxis, platelet GPIb, von Willebrand factor, thrombosis
Current Vascular Pharmacology
Title:Platelets and Platelet Interaction with Progenitor Cells in Vascular Homeostasis and Inflammation
Volume: 10 Issue: 5
Author(s): Kateryna Sopova, Prokopia Tatsidou and Konstantinos Stellos
Affiliation:
Keywords: Platelet, progenitor cells, angiogenesis, vascular homeostasis, ischemia, macrophages, chemotaxis, platelet GPIb, von Willebrand factor, thrombosis
Abstract: Platelet adhesion on vascular wall is the first step following vascular injury. Differential platelet secretion supports angiogenesis and vascular homeostasis. Progenitor cells are pluripotent cells responsible for tissue regeneration and wound healing. Upon ischemia bone marrow-derived progenitor cells are mobilized into peripheral circulation and domiciliate into peripheral organ vasculature and either give birth to a series of cardiovascular cells, including endothelial cells, macrophages, smooth muscle cells, or support in a paracrinic way the angiogenic capacity of local tissue cells. Mobilization, chemotaxis, adhesion, differentiation and interaction with vascular cells are essential steps of progenitor cellmediated tissue repair. This review summarizes the recent advances in our understanding of platelet function with focus on interaction with progenitor cells and its role in cardiovascular homeostasis. Moreover, the role of platelet microparticles in progenitor cell function is separately addressed. Understanding the mechanisms of platelet interaction with progenitor cells provides us with new insights in the mechanisms of vascular homeostasis and possible new therapeutical targets supporting vascular repair.
Export Options
About this article
Cite this article as:
Sopova Kateryna, Tatsidou Prokopia and Stellos Konstantinos, Platelets and Platelet Interaction with Progenitor Cells in Vascular Homeostasis and Inflammation, Current Vascular Pharmacology 2012; 10 (5) . https://dx.doi.org/10.2174/157016112801784486
DOI https://dx.doi.org/10.2174/157016112801784486 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
Call for Papers in Thematic Issues
Ischemic Cardiovascular Diseases: Mechanisms, Diagnosis and Therapy
Ischemic cardiovascular disease includes myocardial infarction, coronary atherosclerotic heart disease, angina pectoris, etc., constitute the leading cause of patient mortality by preventing tissues from getting sufficient oxygen and nutrients. Ischemic heart disease, as a clinical condition, is characterized by myocardial ischemia, causing an imbalance between myocardial blood supply and demand, ...read more
TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Phytocannabinoids and Cannabimimetic Drugs: Recent Patents in Central Nervous System Disorders
Recent Patents on CNS Drug Discovery (Discontinued) Role of Opioid Antagonists in the Treatment of Women with Glucoregulation Abnormalities
Current Pharmaceutical Design Hypoxia and Fetal Heart Development
Current Molecular Medicine Cardiovascular Complications in Diabetes: Lessons from Animal Models
Current Medicinal Chemistry Selective Serotonin Re-Uptake Inhibitors and Hyponatremia in Acutely Medically-Ill Inpatients
Current Drug Safety The Challenges of Blood Pressure Control in Dialysis Patients
Recent Advances in Cardiovascular Drug Discovery (Discontinued) Radiopharmaceuticals Regulations: Current Scenario and the Way Forward
Applied Clinical Research, Clinical Trials and Regulatory Affairs A Link Between Hypertension and Atrial Fibrillation: Methods of Treatment and Prevention
Current Vascular Pharmacology Podophyllotoxin: Current Perspectives
Current Bioactive Compounds A Review of the Cardiovascular and Anti-Atherogenic Effects of Ghrelin
Current Pharmaceutical Design “Cardiovascular” Drugs in Rheumatoid Arthritis: Killing Two Birds with One Stone?
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Potential Use of Nanomedicine for Drug Delivery Across the Blood-Brain Barrier in Healthy and Diseased Brain
CNS & Neurological Disorders - Drug Targets Harnessing the Potential of Long Non-coding RNAs to Manage Metabolic Diseases
Current Pharmaceutical Design Systematic Review of the Role of Microparticles in Systemic Sclerosis
Current Rheumatology Reviews Role of C-Reactive Protein in Acute Myocardial Infarction and Stroke: Possible Therapeutic Approaches
Current Pharmaceutical Biotechnology Markers of Early Vascular Ageing
Current Pharmaceutical Design Natriuretic Peptides in Heart Failure and Post-Myocardial Infarction
Current Hypertension Reviews Von Willebrand Factor and Thrombosis: Risk Factor, Actor and Pharmacological Target
Current Vascular Pharmacology Nutraceuticals and Dietary Supplements to Improve Quality of Life and Outcomes in Heart Failure Patients
Current Pharmaceutical Design The Therapeutic Potential of Hepatocyte Growth Factor for Myocardial Infarction and Heart Failure
Current Pharmaceutical Design