Therapeutic Potential and Strategies Against Leukocyte-Platelet Interaction in Atherosclerosis

Author(s): Peter Seizer, Andreas E. May.

Journal Name: Current Vascular Pharmacology

Volume 10 , Issue 5 , 2012

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Abstract:

Leukocyte rolling, adhesion, transmigration and activation are features of vascular inflammation leading to atherosclerosis. In particular the interaction between platelets and leukocytes is a key process for adhesion of inflammatory cells to the vascular wall. The various mechanisms of the specific platelet-leukocyte interaction may provide a powerful target to prevent initiation and/or progression of atherosclerotic lesions.

Keywords: Atherosclerosis, EMMPRIN, monocytes, platelets, pharmacological inhibition, inflammation, P-Selectin, clopidogrel, cytokines, chemokines

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Article Details

VOLUME: 10
ISSUE: 5
Year: 2012
Page: [550 - 554]
Pages: 5
DOI: 10.2174/157016112801784585
Price: $65

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