Synthesis, Characterization and Antimicrobial Activity of Pyridine-3- Carbonitrile Derivatives

Author(s): Azza M. Abdel-Fattah, Fawzy A. Attaby, Mohamed A. A. Elneairy, Mohmoud N. M. Gouda.

Journal Name:Current Bioactive Compounds

Volume 8 , Issue 2 , 2012


2-Cyanoethanethioamide (1) reacted with α,β-unsaturated ketones 2a,b to afford the corresponding 2- thioxopyridine-3-carbonitrile derivatives 6a,b. The reactivity of the latter products towards various chemical reagents was studied to yield both thieno[2,3-b]pyridines 9a-r and 3-aminothieno[2,3-b]pyridine-2-carbohydrazides 10a,b which were used in turn, to prepare N-phenylmethylenethieno[2,3-b]pyridine-2-carbohydrazides 13a,bpyrido[3`,2`:4,5]thieno[3,2- d]pyrimidinones (15a,b,16a,b) and pyrido[3`,2`:4,5]thieno[3,2-d]triazinones 17a,b. Considering the data of IR,1H NMR, mass spectra and elemental analyses the chemical structures of the newly synthesized heterocyclic compounds were elucidated.

Keywords: Pyridothienotriazinones, 2-Cyanoethanethioamide, Pyridothienopyrimidinones, N-phenylmethylenethienopyridin- 2-carbohydrazides, 2-Thioxopyridine-3-carbonitrile, antimicrobial, carbonitrile derivatives, pyridine, heterocyclic compounds, chemical reagents.

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Article Details

Year: 2012
Page: [176 - 187]
Pages: 12
DOI: 10.2174/157340712801784769
Price: $58