2-Cyanoethanethioamide (1) reacted with α,β-unsaturated ketones 2a,b to afford the corresponding 2-
thioxopyridine-3-carbonitrile derivatives 6a,b. The reactivity of the latter products towards various chemical reagents was
studied to yield both thieno[2,3-b]pyridines 9a-r and 3-aminothieno[2,3-b]pyridine-2-carbohydrazides 10a,b which were
used in turn, to prepare N-phenylmethylenethieno[2,3-b]pyridine-2-carbohydrazides 13a,bpyrido[3`,2`:4,5]thieno[3,2-
d]pyrimidinones (15a,b,16a,b) and pyrido[3`,2`:4,5]thieno[3,2-d]triazinones 17a,b. Considering the data of IR,1H NMR,
mass spectra and elemental analyses the chemical structures of the newly synthesized heterocyclic compounds were elucidated.
Keywords: Pyridothienotriazinones, 2-Cyanoethanethioamide, Pyridothienopyrimidinones, N-phenylmethylenethienopyridin-
2-carbohydrazides, 2-Thioxopyridine-3-carbonitrile, antimicrobial, carbonitrile derivatives, pyridine, heterocyclic compounds, chemical reagents.
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