Recent Trends on QSAR in the Pharmaceutical Perceptions

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Quantitative Structure-Activity Relationship (QSAR) is a field where true multidisciplinary approaches are being used. This volume titled Recent Trends on QSAR in the Pharmaceutical Perceptions ...
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Computer-Based Strategies Towards the Discovery of New Antiepileptic Agents

Pp. 99-118 (20)

Luciana Gavernet, Alan Talevi and Luis E. Bruno-Blanch

Abstract

This chapter overviews recent reports on theoretic, computer-based development of new anticonvulsant agents, including applications of Comparative Molecular Field Analysis, Chemical Graph Theory, Molecular Docking, Similarity Measures, Pharmacophore postulation and Virtual Screening.

Keywords:

Anticonvulsants, epilepsy, antiepileptics, drug design, virtual screening, molecular docking, pharmacophore, QSAR, CoMFA, molecular topology.

Affiliation:

Medicinal Chemistry, Department of Biological Sciences, University of La Plata (UNLP, CCT La Plata - CONICET). 47 and 115, La Plata (B1900AJI), Buenos Aires, Argentina