The presence of chromosomes with diffuse centromeres (holocentric chromosomes) has been reported in several
taxa since more than fifty years, but a full understanding of their origin is still lacking. Comparative and functional
genomics are nowadays furnishing new data to better understand holocentric chromosome evolution thus opening new
perspectives to analyse karyotype rearrangements in species with holocentric chromosomes in particular evidencing unusual
common features, such as the uniform GC content and gene distribution along chromosomes.
Keywords: Holocentrism, holokinetic chromosomes, genome size, gene distribution, GC content, kinetochores, condensin,
chromosome rearrangements, karyotype, cytogenetic analyses
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