Unlocking Holocentric Chromosomes: New Perspectives from Comparative and Functional Genomics?

Author(s): Mauro Mandrioli, Gian Carlo Manicardi.

Journal Name: Current Genomics

Volume 13 , Issue 5 , 2012

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The presence of chromosomes with diffuse centromeres (holocentric chromosomes) has been reported in several taxa since more than fifty years, but a full understanding of their origin is still lacking. Comparative and functional genomics are nowadays furnishing new data to better understand holocentric chromosome evolution thus opening new perspectives to analyse karyotype rearrangements in species with holocentric chromosomes in particular evidencing unusual common features, such as the uniform GC content and gene distribution along chromosomes.

Keywords: Holocentrism, holokinetic chromosomes, genome size, gene distribution, GC content, kinetochores, condensin, chromosome rearrangements, karyotype, cytogenetic analyses

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Article Details

Year: 2012
Page: [343 - 349]
Pages: 7
DOI: 10.2174/138920212801619250
Price: $58

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