Combinatorial Nanoparticles for Cancer Diagnosis and Therapy
A. Mukerjee, A. P. Ranjan and J. K. Vishwanatha
Affiliation: Department of Molecular Biology & Immunology, Director, Institute for Cancer Research, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA.
Nanotechnology when engineered together with biotechnology opens a fascinating field with applications in diverse areas such
as drug targeting and delivery, medical imaging, biosensing, biomaterials and nanotechnology. Conjugating nanoparticles with
biomolecules like QD-herceptin conjugates or QD-aptamer (Apt)-DOX conjugates provides many opportunities for improving many of
the current challenges in cancer diagnosis and therapy. This paper reviews combinatorial nanoparticles designed and formulated for
cancer imaging and therapy, including inorganic nanoparticles (quantum dots, iron oxide particles, gold nanoparticles and silica and
carbon nanoparticles), polymeric nanoparticles (PLGA, PLGA-PEG, PAMAM), liposomes and lipid nanoparticles. These nanoparticles
are multifunctional in nature and combine two or more functions like targeting, imaging and therapy. In this review, we have classified
these combinatorial targeted nanoparticles into inorganic, polymeric and liposome based nanosystems.
Keywords: Nanotechnology, cancer therapy, imaging, inorganic nanoparticles, polymeric nanoparticles, liposomes
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