ELR+ CXC Chemokines and their Role in Malignancy
Pp. 81-87 (7)
Ellen C. Keeley, Borna Mehrad and Robert M. Strieter
The tumor microenvironment is extremely complex and depends on tumor cell interaction
with the responding host cells. Angiogenesis, or new blood vessel growth from pre-existing vasculature,
is a preeminent feature of successful tumor growth of all solid tumors. While a number of factors
produced by both the tumor cells and host responding cells have been discovered that promote tumorassociated
angiogenesis, increasing evidence is growing to support the important role of CXC
chemokines in this process. As a family of cytokines, the CXC chemokines are pleiotropic in their
ability to regulate tumor-associated angiogenesis. In this chapter we will focus on the ELR+ CXC
chemokines and their contribution to tumor-associated angiogenesis.
Angiogenesis, tumor, cytokines.
University of Virginia, Department of Medicine, Division of Pulmonary Critical Care, Box 800466, Charlottesville, Virginia 22908-0466, USA