Activated platelets shed microparticles, which contain a variety of growth factors central to angiogenesis and
neurogenesis. The aim of this study was to explore whether platelet derived microparticles (PMP) can boost endogenous
neural stem cells dependent repair mechanisms following stroke in a rat model.
To examine the effects of PMP therapy in-vivo, we delivered PMP or vehicle via a biodegradable polymer to the brain
surface after permanent middle cerebral artery occlusion (PMCAO) in rats.
Rats were tested with the neurological severity score and infarct volumes were measured at 90 days post-ischemia.
Immunohistochemistry was used to determine the fate of newborn cells and to count blood vessels in the ischemic brain.
The results show that PMP led to a dose dependent increase in cell proliferation, neurogenesis and angiogenesis at the
infarct boundary zone and significantly improved behavioral deficits.
Keywords: Angiogenesis, Cerebral ischemia, Microparticles, Neurogenesis, Platelets, Stroke, endogenous, fibroblastic, platelet microparticles, neural stem cell, brain-derived neurotrophic factor (BDNF), subcellualr fragments, endothelial, PMP, PLX-5A
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