Breaking the Bond: Recent Patents on Bacterial Adhesins

Author(s): Eneas Carvalho, Ana Tung Ching Ching, Patricia Antonia Estima Abreu, Paulo Lee Ho, Angela Silva Barbosa.

Journal Name:Recent Patents on DNA & Gene Sequences (DIscontinued)

Volume 6 , Issue 2 , 2012

Abstract:

Adhesins need to be exposed on the surface of pathogenic bacteria to properly interact with host tissues and allow establishment of the infection. This fact implies that, in theory, one could manage or avoid infection by controlling adhesins’ function, and also by indirectly detecting bacteria through their surface-exposed adhesins. Besides, binding of anti-adhesin immunoglobulins on the bacterial surface tend to promote the opsonization of the pathogen. Therefore, bacterial adhesins represent a great target to develop new biopharmaceuticals, which may become commercially and medically important products. In this review, we will summarize the biological importance of bacterial adhesins, and also discuss some recent patents related to these molecules, as well as their use and possible new future developments in this area.

Keywords: Adhesin, adhesion, antibodies, bacteria, diagnostic, drugs, infectious disease, inhibition, medicament, patent, polypeptide, prophylaxis, protein, treatment, therapy

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2012
Page: [160 - 171]
Pages: 12
DOI: 10.2174/187221512801327352
Price: $100