Breaking the Bond: Recent Patents on Bacterial Adhesins
Ana Tung Ching Ching,
Patricia Antonia Estima Abreu,
Paulo Lee Ho,
Angela Silva Barbosa.
Adhesins need to be exposed on the surface of pathogenic bacteria to properly interact with host tissues and allow
establishment of the infection. This fact implies that, in theory, one could manage or avoid infection by controlling
adhesins’ function, and also by indirectly detecting bacteria through their surface-exposed adhesins. Besides, binding of
anti-adhesin immunoglobulins on the bacterial surface tend to promote the opsonization of the pathogen. Therefore, bacterial
adhesins represent a great target to develop new biopharmaceuticals, which may become commercially and medically
important products. In this review, we will summarize the biological importance of bacterial adhesins, and also discuss
some recent patents related to these molecules, as well as their use and possible new future developments in this area.
Keywords: Adhesin, adhesion, antibodies, bacteria, diagnostic, drugs, infectious disease, inhibition, medicament, patent, polypeptide, prophylaxis, protein, treatment, therapy
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