Small interfering RNAs (siRNAs) are rapidly emerging as new therapeutic tools for the treatment of some of
the deadly diseases such as cancer. However, poor cellular uptake and instability in physiological milieu limit its therapeutic
potential, hence there arises a need of a delivery system which can efficiently and repeatedly deliver siRNA to the
target cells. Nanoparticles have shown immense potential as suitable delivery vectors with enhanced efficacy and biocompatibility.
These delivery vectors are usually few nanometers in size, which not only protects siRNA against enzymatic
degradation but also leads to tissue and cellular targeting. Nanoparticles prepared from various cationic polymers
like polyethylenimine, and chitosan have been largely exploited as they bear several advantages such as, ease of manipulation,
high stability, low cost and high payload. This review summarizes some of the recent patents on siRNA delivery
employing polymer or lipid-based nano-vectors for therapeutic applications.
Keywords: Biocompatibility, biodegradability, cationic, chitosan, degradation, delivery, lipoplexes, liposome, lipids, nanoparticles, nano-vectors, polyarginine, polymer, siRNA, therapeutic
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