Advances in Lentiviral Vectors: A Patent Review
Elisa Maria de Sousa Russo-Carbolante,
Dimas Tadeu Covas.
Lentiviral vectors are at the forefront of gene delivery systems for research and clinical applications. These vectors
have the ability to efficiently transduce nondividing and dividing cells, to insert large genetic segment in the host
chromatin, and to sustain stable long-term transgene expression. Most of lentiviral vectors systems in use are derived from
HIV-1. Numerous modifications in the basic HIV structure have been made to ensure safety and to promote efficiency to
vectors. Lentiviral vectors can be pseudotyped with distinct viral envelopes that influence vector tropism and transduction
efficiency. Moreover, these vectors can be used to reprogram cells and generate induced pluripotent stem cells. This review
aims to show the patents that resulted in improved safety and efficacy of lentiviral vector with important implications
for clinical trials.
Keywords: Lentiviral vectors, vector design, applications, vector tropism, pluripotent stem cells, Retroviridae, Simian immunodeficiency virus, Feline immunodeficiency virus
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