Scandium-44: Benefits of a Long-Lived PET Radionuclide Available from the 44Ti/44Sc Generator System

Author(s): Frank Roesch.

Journal Name: Current Radiopharmaceuticals

Volume 5 , Issue 3 , 2012

Abstract:

44Ti/44Sc radionuclide generators are of interest for molecular imaging. The 3.97 hours half-life of 44Sc and its high positron branching of 94.27% may stimulate the application of 44Sc-labeled PET radiopharmaceuticals. This review describes the current status of 44Ti production, 44Ti/44Sc radionuclide generator development, post-processing of generator eluates towards medical application, identification of ligands adequate to ScIII co-ordination chemistry, proof-of-principle labeling of 44Sc-DOTA-octreotides, investigation of in vitro and in vivo parameters, and initial applications for molecular imaging – both in small animals and humans.

Keywords: Titanium-44, Scandium-44, Radionuclide generator, Post-processing, DOTA, Octreotide, Positron emission, PET, COST

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Article Details

VOLUME: 5
ISSUE: 3
Year: 2012
Page: [187 - 201]
Pages: 15
DOI: 10.2174/1874471011205030187
Price: $58

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