Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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2,3-Disubtituted Thiazolidin-4-ones: Novel Class of Anticonvulsant Agents

Author(s): M. Senthilraja, V. Alagarsamy, V. Raja Solomon.

Abstract:

A new series of 2,3-disubstituted thiazolidin-4-ones were synthesized from the appropriate amines, substituted aldehyde, and mercaptoacetic acid in the presence of DCC in anhydrous THF by microwave irradiation. The title compounds were investigated for their anticonvulsant activity. Among the test compounds, compound 2-(4- bromophenyl)-2-methylthiazolidin-4-one-3-isonicotinamide (8) emerged as most active compound of the series and it is moderately more potent than the reference standard diazepam.

Keywords: Thiazolidinone, Anti-convulsant activity. Microwave-irradiation, AED, Epilepsy, mercapto acid, DCC, microwave irradiation, AED, anti-inflammatory, cholerectic, anti-HIV, MCRs, Thomas Hoover melting point, FT-NMR spectrometer

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Article Details

VOLUME: 9
ISSUE: 7
Year: 2012
Page: [731 - 735]
Pages: 5
DOI: 10.2174/157018012801319517
Price: $58