2,3-Disubtituted Thiazolidin-4-ones: Novel Class of Anticonvulsant Agents
V. Raja Solomon.
A new series of 2,3-disubstituted thiazolidin-4-ones were synthesized from the appropriate amines, substituted
aldehyde, and mercaptoacetic acid in the presence of DCC in anhydrous THF by microwave irradiation. The title
compounds were investigated for their anticonvulsant activity. Among the test compounds, compound 2-(4-
bromophenyl)-2-methylthiazolidin-4-one-3-isonicotinamide (8) emerged as most active compound of the series and it is
moderately more potent than the reference standard diazepam.
Keywords: Thiazolidinone, Anti-convulsant activity. Microwave-irradiation, AED, Epilepsy, mercapto acid, DCC, microwave irradiation, AED, anti-inflammatory, cholerectic, anti-HIV, MCRs, Thomas Hoover melting point, FT-NMR spectrometer
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