New Class of Triazole Derivatives and Their Antimicrobial Activity
Sreekanth B. Jonnalagadda.
A new series of 1,2,4-triazole derivatives 3a-i of (E)-4-(4-substitutedbenzylideneamino)-3-((5-phenyl-1,3,4-
oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione (2) were synthesized, deriving from 4-amino-3-((5-phenyl-1,3,4-
oxadiazol-2-yl)methyl-1H-1,2,4-triazole-5(4H)-thione (1). The compounds were elucidated by IR, 1H NMR, 13C NMR,
MS and elemental analyses. These compounds were screened for their antimicrobial activity. Among the synthesized
triazole-5(4H)-thione, 3c was found to exhibit most potent In vitro antimicrobial activity with minimum inhibitory
concentrations (MIC) of 1.56, 3.125, 1.56, 25, 25 and 25 μg/ml against E. coli, S. typhimurium, L. monocytogenes, S.
aureus, P. aeruginosa and S. pyogenes respectively. Compound (E)-4-(benzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-
2-yl)methyl)-2-(morpholinmethyl)-1H-1,2,4-triazole-5(4H)-thione 3a was found to exhibit most potent In vitro antifungal
activity with MICs 0.78 and 0.097 μg/ml against C. albicans and F. solani.
Keywords: Antibacterial activity, Antifungal activity, Minimum inhibitory concentration, Synthesis, Triazole derivatives,
1, 2, 4-Triazole-5(4H)-thione, 1H NMR, E. coli, S. typhimurium, L. monocytogenes, S. aureus, P. aeruginosa, S. pyogenes, F. solani, agrochemical fields, antihypertensive
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