Simple C-2-Substituted Quinolines and their Anticancer Activity

Title:Simple C-2-Substituted Quinolines and their Anticancer Activity

Volume: 9 Issue: 7

Author(s): Vladimir V. Kouznetsov, Fernando A. Rojas Ruiz, Leonor Y. Vargas Mendez and Mahabir P. Gupta

Affiliation:

Keywords: C-2-aryl quinoline derivatives, Synthesis, Anticancer activity, Cytotoxicity on normal cells, Toxic effects in silico, MCF-7, cytotoxic effect, Biological activity, SAR results, pathological proliferation , cisplatin, adriamycin, doxorubicin, anthracycline, antibiotic

Abstract: Sixteen C-2-substituted quinolines were tested in both human cancer cell lines (MCF-7, H-460 and SF-268) and normal cell lines (Vero and THP-1). Preliminary results indicate that 2-α-furyl- and 2-γ-pyridinyl quinoline derivatives 1, 13 and 14 are active against three human cancer cell lines and, at the same time, were devoid of cytotoxic effect on normal cells. Biological activity and SAR results were compared with different molecular descriptors determined in silico using online available software, in an attempt to show a relationship with the possible mode of action of these quinoline derivatives.

Cite this article as:

V. Kouznetsov Vladimir, A. Rojas Ruiz Fernando, Y. Vargas Mendez Leonor and P. Gupta Mahabir, Simple C-2-Substituted Quinolines and their Anticancer Activity, Letters in Drug Design & Discovery 2012; 9 (7) . https://dx.doi.org/10.2174/157018012801319544