Antioxidant Activity of Synthetic Resveratrol Analogs: A Structure- Activity Insight
Natalia Oliveira Calil, Gustavo Senra Goncalves de Carvalho, Annelisa Farah da Silva, Adilson David da Silva and Nadia Rezende Barbosa Raposo
Pages 676-679 (4)
This study evaluated the antioxidant activity of five resveratrol analogs using the DPPH method. The molecules
activity was related with their chemical structure. Besides descriptive statistics, the analysis of variance (ANOVA)
followed by Tukey’s post hoc test were performed (p<0.05). The antioxidant activity of analogs A and B was statistically
similar with each other and from the reference standard resveratrol, possibly due to the presence of 4-hydroxy grouping.
The aromatic hydroxyl reduces reactive free radicals and produces phenoxyl radical, stabilized by resonance. Although
the analog C has shown IC50 value statistically different from the resveratrol (p<0.001), its antioxidant activity was
considered satisfactory. The other analogs (D and E), which have a 4-acid grouping in place of 4-hydroxy grouping,
showed lower antioxidant activity than resveratrol (p<0.001). Further studies to address possible advantages of analogs in
relation to resveratrol should be conducted in order to make them feasible for therapeutic use.
Analogs, Antioxidant Activity, Chemical Synthesis, Hydroxylation, Resveratrol, Structure-Activity Relationship, ANOVA, Tukey’s post hoc test, aromatic hydroxyl, resveratrol, DPPH method, hydroxy grouping, fibroblasts clonogenic cell, chemoprevention
NUPICS, Faculdade de Farmacia, Universidade Federal de Juiz de Fora, Juiz de Fora, M.G. 36036- 330, Brazil.