Solid-Phase Microwave Assisted Synthesis of Curcumin Analogs

Author(s): Dinesh Pore, Ramesh Alli, Achanta S.C. Prabhakar, Rajashekar R. Alavala, Umasankar Kulandaivelu, Shireesha Boyapati.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 6 , 2012

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Abstract:

Turmeric contains three important analogs, curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), collectively called as curcuminoids. Curcumin, the most abundant of these curcuminoids is reported to have antioxidant, anti-inflammatory, neuroprotective, antimicrobial, nematocidal, antimutagenic, anticarcinogenic, antiretroviral and chemopreventive activities. Curcumin (a symmetric β diketone) analogs 3a-e were synthesized from β- diketones and aromatic aldehydes using solid phase microwave irradiation method in presence of boric acid in diethanolamine, acetic acid (1:1) with reduced reaction time and enhanced %yield. Various clays like Alumina (neutral), Silica gel and Montmorillonite K10 were used as solid phase catalysts where alumina was found to be efficient in the synthesis of curcumin analogs

Keywords: Aldol condensation, boron-assisted, curcumin analogs, microwave irradiation, regioselective, solid-phase, anticarcinogenic, antimutagenic, chemopreventive, antiretroviral

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2012
Page: [447 - 450]
Pages: 4
DOI: 10.2174/157017812801322417
Price: $65

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